Plague Inc. Bacteria Mega-Brutal Guide/ Walkthrough

After a lot of frustrating games, I was finally able to find a good strategy to beat Bacteria on Mega-Brutal difficulty. This mode is much harder than brutal. Mega-Brutal difficulty actually makes brutal difficulty seem like casual. This is mainly because of the the random events that happen while playing in Mega-Brutal. Random checks will always detect your virus even before you are able to evolve a single symptom. Genetic Shifts causes DNA costs of everything to fluctuate, which means the costs of evolution will increase or decrease randomly(In my experience, it increases most of the time).

I have tried this strategy over and over again to make sure it works and I can confidently say that it does, all the time. My average stats at the end of the game are 400+ days, 30~40% Cure Completion and 4/5 or 5/5 Biohazards.

Before we start the guide, I should let you know about the various things that could happen while playing at this super hard difficulty. First off, Your plague will most likely be detected early on even without any evolved symptoms, this is mainly because of the random blood tests a country conducts. Second, DNA costs will tend to increase without anything to warn you about it. Lastly, a lot of random events happen. Awareness days and countries closing itself off tend to happen a lot.

Let's begin.

Gene setup:

ATP Boost

Aquacyte

Sympto-Stasis

Genetic Mimic

Extremophile

1.) Start in China

2.) Evolve these transmissions: Water 1 and Insect 1

3.) Evolve the following symptoms:

Nausea

Coughing

Rash

Cysts

Anaemia

Vomiting

Pneumonia

Sneezing

Sweating

Hyper Sensitivity

Abscesses

Haemophilia

4.) Continue to evolve these transmissions: Water 2 and Insect 2

5.) Evolve these symptoms if they haven't mutated yet:

Diarrhoea

Pulmonary Oedema

Skin Lesions

6.) Evolve the following abilities

Drug Resistance 1

Bacterial Resilience 1, 2, and 3

Drug Resistance 2

Genetic Hardening 1 and 2

7.) Back to symptoms, evolve these if they haven't mutated yet:

Insomnia

Paranoia

Seizures

Insanity

Paralysis

Coma

Necrosis

Dysentery (This one is optional, I sometimes evolve this to make infection faster. It's a bit lethal though)

8.) At this point you have to wait until the whole world is infected(a pop-up appears). This shouldn't take long. Evolve some Genetic Re-Shuffles if you feel the need to do so. I use all three of mine when the cure progress reaches 40%.

9.) After getting the "there's no one healthy left" pop-up, evolve every lethal symptom you possibly can. But by this point, you've probably already killed at least 80% of the population.

10.) Congratulations on beating Bacteria in Mega-Brutal difficulty.

There might be a chance that island countries such as Greenland and Madagascar close their ports/harbors. This makes it impossible to infect these countries. This never happens when I use this strategy, but on some rare occasion that it does happen just start your game over.